Smad6 (NM_008542) Mouse Recombinant Protein

• Background:

  Binds to regulatory elements in target promoter regions (By similarity) . May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding (By similarity) . Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  B2b390Clo; Madh6

• Gene ID:

  17130

• UniProt:

  O35182

• Accession Number mRNA:

  NM_008542

• Chromosomal Location:

  9 C

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  54.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Smad6

• Species:

  Mouse

• Protein ID:

  NP_032568

• Overview:

  Purified recombinant protein of Mouse SMAD family member 6 (Smad6), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/17130

• Uniprot URL:

  https://www.uniprot.org/uniprot/O35182

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_008542

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_032568