SKIP (INPP5K) (NM_001135642) Human Recombinant Protein

• Background:

  This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

• Synonyms:

  MDCCAID; PPS; SKIP

• Gene ID:

  51763

• UniProt:

  Q9BT40, Q9BT40-2

• Accession Number mRNA:

  NM_001135642

• Chromosomal Location:

  17p13.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Inositol phosphate metabolism, Insulin signaling pathway, Metabolic pathways, Phosphatidylinositol signaling system

• Field of Research:

  Inositol phosphate metabolism, Insulin signaling pathway, Metabolic pathways, Phosphatidylinositol signaling system

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Phosphatase

• Molecular Weight:

  42.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  INPP5K

• Species:

  Human

• Protein ID:

  NP_001129114

• Overview:

  Recombinant protein of human inositol polyphosphate-5-phosphatase K (INPP5K), transcript variant 3

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/51763

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9BT40

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001135642

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001129114