Inpp5k (NM_008916) Mouse Recombinant Protein

• Background:

  Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (By similarity) . Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (PubMed:22247557, PubMed:22751929) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  C62; Pps; SKIP

• Gene ID:

  19062

• UniProt:

  Q8C5L6, Q5ND43

• Accession Number mRNA:

  NM_008916

• Chromosomal Location:

  11 45.92 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  54.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Inpp5k

• Species:

  Mouse

• Protein ID:

  NP_032942

• Overview:

  Purified recombinant protein of Mouse inositol polyphosphate 5-phosphatase K (Inpp5k), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/19062

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8C5L6

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_008916

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_032942