TRAIL (TNFSF10) (NM_003810) Human Recombinant Protein

• Background:

  The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

• Synonyms:

  Apo-2L; APO2L; CD253; TL2; TNLG6A; TRAIL

• Gene ID:

  8743

• UniProt:

  P50591, Q6IBA9

• Accession Number mRNA:

  NM_003810

• Chromosomal Location:

  3q26.31

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

• Field of Research:

  Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris, 8M Urea, pH8.0.

• Function:

  Druggable Genome, Transmembrane

• Molecular Weight:

  28.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TNFSF10

• Species:

  Human

• Protein ID:

  NP_003801

• Overview:

  Purified recombinant protein of Human tumor necrosis factor (ligand) superfamily, member 10 (TNFSF10), transcript variant 1, Thr39-End, with N-terminal His tag, expressed in E.coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/8743

• Uniprot URL:

  https://www.uniprot.org/uniprot/P50591

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_003810

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_003801