TRAIL (TNFSF10) Mouse Monoclonal Antibody [Clone ID: LBI9A8]

• Background:

  The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

• Synonyms:

  Apo-2L; APO2L; CD253; TL2; TRAIL

• Gene Name:

  Homo sapiens TNF superfamily member 10 (TNFSF10), transcript variant 1, mRNA.

• Gene ID:

  8743

• UniProt:

  P50591

• Conjugation:

  Unconjugated

• Related Pathways:

  Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

• Field of Research:

  Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

• Dilution:

  WB 1:500

• Form:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Buffer:

  Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

• Function:

  Druggable Genome, Transmembrane

• Storage Conditions:

  Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  TNFSF10

• Overview:

  Carrier-free (BSA/glycerol-free) TNFSF10 mouse monoclonal antibody, clone LBI9A8

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=8743

• Uniprot URL:

  https://www.uniprot.org/uniprot/P50591