MSH2 (NM_000251) Human Recombinant Protein

• Background:

  This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

• Synonyms:

  COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; MMRCS2

• Gene ID:

  4436

• UniProt:

  P43246

• Accession Number mRNA:

  NM_000251

• Chromosomal Location:

  2p21-p16.3

• Expression System:

  E. coli

• Tag:

  N-His

• Related Pathways:

  Colorectal cancer, Mismatch repair, Pathways in cancer

• Field of Research:

  Colorectal cancer, Mismatch repair, Pathways in cancer

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150mM NaCl, 10% glycerol

• Function:

  Druggable Genome, Stem cell - Pluripotency

• Molecular Weight:

  12.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  MSH2

• Species:

  Human

• Protein ID:

  NP_000242

• Overview:

  Purified recombinant protein of Human mutS homolog 2, colon cancer, nonpolyposis type 1 (E.coli) (MSH2), Tyr815-Asn920, with N-terminal His tag, expressed in E.coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/4436

• Uniprot URL:

  https://www.uniprot.org/uniprot/P43246

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_000251

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_000242