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Cflar (BC023121) Mouse Recombinant Protein

CAT: 0882-PM49224M5Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PM49224M5Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse CASP8 and FADD-like apoptosis regulator (cDNA clone MGC:28609 IMAGE:4218551), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
MRIT, CLARP, FLAME, Casper, I-FLICE, Flip
Gene ID
12633
UniProt
O35732
Accession Number mRNA
BC023121
Chromosomal Location
1 29.16 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
74 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Cflar
Species
Mouse
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/12633
Uniprot URL
https://www.uniprot.org/uniprot/O35732
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC023121

UniProtKB · O35732

CASP8 and FADD-like apoptosis regulator

CFLAR_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
O35732
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Cflar
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
D3Z0W6, O35707, O35733
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Technical term

Reference proteome

Domain

Repeat

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