Cxcl10 (NM_021274) Mouse Recombinant Protein

• Background:

  Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity) (PubMed:28623423) . Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (PubMed:18624292, PubMed:19017990, PubMed:28468883) . Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (By similarity) . Activation of the CXCL10/CXCR3 axis plays also an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (PubMed:15456824) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  C7; CRG-2; gIP-10; Ifi10; INP10; IP-10; IP10; mob-1; Scyb10

• Gene ID:

  15945

• UniProt:

  P17515, Q548V9

• Accession Number mRNA:

  NM_021274

• Chromosomal Location:

  5 46.57 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  10.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Cxcl10

• Species:

  Mouse

• Protein ID:

  NP_067249

• Overview:

  Purified recombinant protein of Mouse chemokine (C-X-C motif) ligand 10 (Cxcl10), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/15945

• Uniprot URL:

  https://www.uniprot.org/uniprot/P17515

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_021274

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_067249