Bloc1s1 (NM_015740) Mouse Recombinant Protein

• Background:

  Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:16760431, PubMed:19546860, PubMed:21998198) . As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. The BORC complex is most probably associated with the cytosolic face of lysosomes, may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AI839753; BLOS1; Gcn5l1

• Gene ID:

  14533

• UniProt:

  O55102

• Accession Number mRNA:

  NM_015740

• Chromosomal Location:

  10 77.19 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  14.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Bloc1s1

• Species:

  Mouse

• Protein ID:

  NP_056555

• Overview:

  Purified recombinant protein of Mouse biogenesis of lysosomal organelles complex-1, subunit 1 (Bloc1s1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/14533

• Uniprot URL:

  https://www.uniprot.org/uniprot/O55102

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_015740

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_056555