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Cops7a (NM_012003) Mouse Recombinant Protein

CAT: 0882-PM47682M5Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PM47682M5Size:20 µg
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Background
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse COP9 signalosome subunit 7A (Cops7a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
D6Ertd35e; SGN7a
Gene ID
26894
UniProt
Q9CZ04
Accession Number mRNA
NM_012003
Chromosomal Location
6 59.17 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
30.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Cops7a
Species
Mouse
Protein ID
NP_036133
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/26894
Uniprot URL
https://www.uniprot.org/uniprot/Q9CZ04
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/NM_012003
Protein ID Link
https://www.ncbi.nlm.nih.gov/nuccore/NP_036133

UniProtKB · Q9CZ04

COP9 signalosome complex subunit 7a

CSN7A_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q9CZ04
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Cops7a
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
SGN7a, Signalosome subunit 7a
EC number
—
Processing
—
Secondary accessions
O88546, Q925R8, Q9CPQ4, Q9CWD2
Protein keywords

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Domain

Coiled coil

Cellular component

CytoplasmNucleusSignalosome

Technical term

Reference proteome

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