Fgl1 (NM_145594) Mouse Recombinant Protein

• Background:

  Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966) . Responsible for LAG3 T-cell inhibitory function (PubMed:30580966) . Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966) . In addition to its role in inhibiting inflammatory immune responses, also plays a role in hepatocytes (By similarity) . Under normal physiological conditions, primarily secreted from hepatocytes and contributes to its mitogenic and metabolic functions (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  Mfire1

• Gene ID:

  234199

• UniProt:

  Q71KU9, A0A0R4J0E1

• Accession Number mRNA:

  NM_145594

• Chromosomal Location:

  8 A4

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  36.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Fgl1

• Species:

  Mouse

• Protein ID:

  NP_663569

• Overview:

  Purified recombinant protein of Mouse fibrinogen-like protein 1 (Fgl1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/234199

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q71KU9

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_145594

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_663569