FGL1 Rabbit mAb (AMR11543N)

• Background:

  Fibrinogen-like protein 1 (FGL1), a liver-secreted protein, is a major LAG-3 functional ligand independent from MHC-II. The FGL1-LAG-3 pathway maybe an important immune evasion mechanism and could contribute to current cancer immunotherapy efforts for several reasons. FGL1 inhibits antigen-specific T cell activation, and ablation of FGL1 in mice promotes T cell immunity. Blockade of the FGL1-LAG-3 interaction by monoclonal antibodies stimulates tumor immunity and is therapeutic against established mouse tumors in a receptor-ligand inter-dependent manner. FGL1 is highly produced by human cancer cells, and elevated FGL1 in the plasma of cancer patients is associated with a poor prognosis and resistance to anti-PD-1/B7-H1 therapy

• Synonyms:

  FGL1; HFREP1; HP-041; LFIRE-1; LFIRE1

• Gene ID:

  2267

• UniProt:

  Q08830

• Cellular Locus:

  Secreted

• Dilution:

  WB 1:500 - 1:1000

• Form:

  Liquid

• Buffer:

  Buffer: PBS with 0.09% sodium azide, 50% glycerol, pH7.4.

• Molecular Weight:

  Calculated MW: 36kDa Observed MW: 35kDa

• Storage Conditions:

  Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FGL1 Rabbit mAb (APR24560N5) .

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2267

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q08830

• AA Sequence:

  Email for sequence