Elavl1 (BC016194) Mouse Recombinant Protein

CAT: 0882-PM47264M5Size: 20 µgDry Ice: NoHazardous: No

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CAT#:0882-PM47264M5Size:20 µg

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Background

RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (PubMed:24394384) . Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (By similarity) . With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (PubMed:21402775) . Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:27616329) .[UniProtKB/Swiss-Prot Function]

Overview

Purified recombinant protein of Mouse ELAV (embryonic lethal, abnormal vision, Drosophila) -like 1 (Hu antigen R) (cDNA clone MGC:27577, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

Synonyms

HUR

Gene ID

15568

UniProt

P70372

Accession Number mRNA

BC016194

Chromosomal Location

8 2.0 cM

Expression System

HEK293T

Tag

C-MYC/DDK

Concentration

>50 ug/mL as determined by microplate BCA method

Purity

> 80% as determined by SDS-PAGE and Coomassie blue staining

Form

Liquid

Buffer

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Molecular Weight

90.8 kDa

Storage Conditions

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Symbol

Elavl1

Species

Mouse

Gene ID URL

https://www.ncbi.nlm.nih.gov/gene/15568

Uniprot URL

https://www.uniprot.org/uniprot/P70372

Accession Number mRNA URL

https://www.ncbi.nlm.nih.gov/nuccore/BC016194

UniProtKB · P70372

ELAV-like protein 1

ELAV1_MOUSE · Mus musculus

View on UniProt ↗

Primary accession: P70372
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: Elavl1
Protein existence: 1: Evidence at protein level
Organism: Mus musculus (Mouse)
Taxonomy ID: 10090
Alternative names: —
EC number: —
Processing: —
Secondary accessions: Q60745, Q78QY3

Protein keywords

PTM

AcetylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Cellular component

CytoplasmNucleus

Technical term

Reference proteome

Domain

Repeat

Molecular function

RNA-binding

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Catalog	Name
E45M47264M5	Elavl1 (BC016194) Mouse Recombinant Protein
TP727653	Mouse Recombinant Protein
RPM-236	RECOMBINANT MOUSE PROTEIN
MR204748A1V	Mouse Elavl1 (BC016194) AAV Particle
MG204748	Elavl1 (BC016194) Mouse Tagged ORF Clone
MR204748L3	Elavl1 (BC016194) Mouse Tagged Lenti ORF Clone
MR204748L3V	Elavl1 (BC016194) Mouse Tagged ORF Clone Lentiviral Particle