Ppm1a (NM_008910) Mouse Recombinant Protein

• Background:

  Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity) . Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  2310003C21Rik; 2900017D14Rik; AI427932; AU017636; MMPa-2; MPPa-1

• Gene ID:

  19042

• UniProt:

  P49443, Q9EQE3

• Accession Number mRNA:

  NM_008910

• Chromosomal Location:

  12 C3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  42.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Ppm1a

• Species:

  Mouse

• Protein ID:

  NP_032936

• Overview:

  Purified recombinant protein of Mouse protein phosphatase 1A, magnesium dependent, alpha isoform (Ppm1a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/19042

• Uniprot URL:

  https://www.uniprot.org/uniprot/P49443

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_008910

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_032936