Hmbox1 (BC051457) Mouse Recombinant Protein

• Background:

  Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (By similarity) . Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (By similarity) . Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (PubMed:23685356) . Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (By similarity) . Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (By similarity) . Might also be involved in the DNA damage response at telomeres (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AI451877; AI604847; F830020C16Rik

• Gene ID:

  219150

• UniProt:

  Q8BJA3

• Accession Number mRNA:

  BC051457

• Chromosomal Location:

  14 D1

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  45.4 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Hmbox1

• Species:

  Mouse

• Overview:

  Purified recombinant protein of Mouse homeobox containing 1 (cDNA clone MGC:56991 IMAGE:6398463), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/219150

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8BJA3

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/BC051457