HMBOX1 (NM_001135726) Human Recombinant Protein

• Background:

  Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356) . Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356) . Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity) . Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958) . Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958) . Might also be involved in the DNA damage response at telomeres (PubMed:23813958) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  HNF1LA; HOT1; PBHNF; TAH1

• Gene ID:

  79618

• UniProt:

  Q6NT76

• Accession Number mRNA:

  NM_001135726

• Chromosomal Location:

  8p21.1-p12

• Expression System:

  E. coli

• Tag:

  N-His

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25mM Tris, pH8.0, 150mM NaCl, 10% glycerol, 1% Sarkosyl.

• Function:

  Transcription Factors

• Molecular Weight:

  47.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  HMBOX1

• Species:

  Human

• Protein ID:

  NP_001129198

• Overview:

  Purified recombinant protein of Human homeobox containing 1 (HMBOX1), transcript variant 2, full length, with N-terminal HIS tag, expressed in E.coli, 50ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/79618

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q6NT76

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001135726

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001129198