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Wdr4 (BC039272) Mouse Recombinant Protein

CAT: 0882-PM46568M5Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PM46568M5Size:20 µg
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Background
Non-catalytic component of a methyltransferase complex required for the formation of N (7) -methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:29983320) . In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit (By similarity) . Required for the formation of N (7) -methylguanine at position 46 (m7G46) in tRNA (PubMed:29983320) . Also required for the formation of N (7) -methylguanine at internal sites in a subset of mRNAs (By similarity) . Also required for methylation of a specific subset of miRNAs, such as let-7 (By similarity) . Acts as a regulator of embryonic stem cell self-renewal and differentiation (PubMed:29983320) . Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1 (PubMed:29574139) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse WD repeat domain 4 (cDNA clone MGC:35877 IMAGE:5027600), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
AI415180; AI448349; D530049K22Rik
Gene ID
57773
UniProt
Q9EP82
Accession Number mRNA
BC039272
Chromosomal Location
17 B1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
45.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Wdr4
Species
Mouse
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/57773
Uniprot URL
https://www.uniprot.org/uniprot/Q9EP82
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC039272

UniProtKB · Q9EP82

tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4

WDR4_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q9EP82
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Wdr4
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q80V01
Protein keywords

PTM

AcetylationPhosphoprotein

Cellular component

ChromosomeNucleus

Biological process

DNA damagetRNA processing

Technical term

Reference proteome

Domain

RepeatWD repeat

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