Il1r2 (BC032962) Mouse Recombinant Protein

• Background:

  Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  CD121b; Il1r-2

• Gene ID:

  16178

• UniProt:

  P27931

• Accession Number mRNA:

  BC032962

• Chromosomal Location:

  1 18.65 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  31.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Il1r2

• Species:

  Mouse

• Overview:

  Purified recombinant protein of Mouse interleukin 1 receptor, type II (cDNA clone MGC:41170 IMAGE:1282531), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/16178

• Uniprot URL:

  https://www.uniprot.org/uniprot/P27931

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/BC032962