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Mark3 (BC026445) Mouse Recombinant Protein

CAT: 0882-PM46428M5Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PM46428M5Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAPT/TAU, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse MAP/microtubule affinity-regulating kinase 3 (cDNA clone MGC:31426 IMAGE:4459439), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
ETK-1, Emk2
Gene ID
17169
UniProt
Q03141
Accession Number mRNA
BC026445
Chromosomal Location
12 F1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
47.2 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Mark3
Species
Mouse
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/17169
Uniprot URL
https://www.uniprot.org/uniprot/Q03141
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC026445

UniProtKB · Q03141

MAP/microtubule affinity-regulating kinase 3

MARK3_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q03141
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Mark3
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4
Protein keywords

Technical term

3D-structureReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCell projectionCytoplasmMembrane

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

Phosphoprotein

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