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Tnip2 (BC052083) Mouse Recombinant Protein

CAT: 0882-PM46303M5Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PM46303M5Size:20 µg
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Background
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse TNFAIP3 interacting protein 2 (cDNA clone MGC:62501 IMAGE:6404610), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
1810020H16Rik; ABIN-2; AI428870
Gene ID
231130
UniProt
Q99JG7
Accession Number mRNA
BC052083
Chromosomal Location
5 B2
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
51.6 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Tnip2
Species
Mouse
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/231130
Uniprot URL
https://www.uniprot.org/uniprot/Q99JG7
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC052083

UniProtKB · Q99JG7

TNFAIP3-interacting protein 2

TNIP2_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q99JG7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Tnip2
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q3TVF3
Protein keywords

Biological process

ApoptosisInflammatory responseTranscriptionTranscription regulation

Domain

Coiled coilZinc-finger

Cellular component

Cytoplasm

Ligand

Metal-bindingZinc

PTM

PhosphoproteinUbl conjugation

Technical term

Reference proteome

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