Bin1 (NM_001083334) Mouse Recombinant Protein

• Background:

  Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:12183633) . Is a negative regulator of endocytosis (By similarity) . Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:12668730, PubMed:27179792) . In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity) . May be involved in the regulation of MYC activity and the control cell proliferation (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  ALP-1; Amphl; BRAMP-2; SH3P9

• Gene ID:

  30948

• UniProt:

  Q6P1B9

• Accession Number mRNA:

  NM_001083334

• Chromosomal Location:

  18 18.01 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  52.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Bin1

• Species:

  Mouse

• Protein ID:

  NP_001076803

• Overview:

  Purified recombinant protein of Mouse bridging integrator 1 (Bin1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/30948

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q6P1B9

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001083334

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001076803