BIN1 (NM_004305) Human Recombinant Protein

• Background:

  This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016]

• Synonyms:

  AMPH2; AMPHL; CNM2; SH3P9

• Gene ID:

  274

• UniProt:

  O00499, A0A024RAE9

• Accession Number mRNA:

  NM_004305

• Chromosomal Location:

  2q14.3

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  50 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  BIN1

• Species:

  Human

• Protein ID:

  NP_004296

• Overview:

  Recombinant protein of human bridging integrator 1 (BIN1), transcript variant 8

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/274

• Uniprot URL:

  https://www.uniprot.org/uniprot/O00499

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_004305

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_004296