Kmo (NM_133809) Mouse Recombinant Protein

• Background:

  Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn) . Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AI046660

• Gene ID:

  98256

• UniProt:

  Q91WN4

• Accession Number mRNA:

  NM_133809

• Chromosomal Location:

  1 H3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  55 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Kmo

• Species:

  Mouse

• Protein ID:

  NP_598570

• Overview:

  Purified recombinant protein of Mouse kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (Kmo), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/98256

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q91WN4

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_133809

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_598570