Bace1 (NM_011792) Mouse Recombinant Protein

• Background:

  This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. Homozygous knockout mice for this gene exhibit a wide range of nervous system defects, growth retardation, metabolic abnormalities, and increased neonatal lethality. [provided by RefSeq, Nov 2015]

• Synonyms:

  ASP2; Bace; C76936

• Gene ID:

  23821

• UniProt:

  P56818, Q8C4F4

• Accession Number mRNA:

  NM_011792

• Chromosomal Location:

  9 A5.2

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  55.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Bace1

• Species:

  Mouse

• Protein ID:

  NP_035922

• Overview:

  Purified recombinant protein of Mouse beta-site APP cleaving enzyme 1 (Bace1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/23821

• Uniprot URL:

  https://www.uniprot.org/uniprot/P56818

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_011792

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_035922