Dync1li1 (NM_146229) Mouse Recombinant Protein

• Background:

  Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  1110053F02Rik; Dnclic1; LIC-1

• Gene ID:

  235661

• UniProt:

  Q8R1Q8, Q3TWG5

• Accession Number mRNA:

  NM_146229

• Chromosomal Location:

  9 F3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  56.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Dync1li1

• Species:

  Mouse

• Protein ID:

  NP_666341

• Overview:

  Purified recombinant protein of Mouse dynein cytoplasmic 1 light intermediate chain 1 (Dync1li1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/235661

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8R1Q8

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_146229

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_666341