Sh2b3 (NM_008507) Mouse Recombinant Protein

• Background:

  This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

• Synonyms:

  AI429800; L; Lnk

• Gene ID:

  16923

• UniProt:

  O09039

• Accession Number mRNA:

  NM_008507

• Chromosomal Location:

  5 61.99 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  60.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Sh2b3

• Species:

  Mouse

• Protein ID:

  NP_032533

• Overview:

  Purified recombinant protein of Mouse SH2B adaptor protein 3 (Sh2b3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/16923

• Uniprot URL:

  https://www.uniprot.org/uniprot/O09039

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_008507

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_032533