Men1 (NM_001168490) Mouse Recombinant Protein

• Background:

  Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4) . Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression (By similarity) . May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AW045611

• Gene ID:

  17283

• UniProt:

  O88559

• Accession Number mRNA:

  NM_001168490

• Chromosomal Location:

  19 A

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  61.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Men1

• Species:

  Mouse

• Protein ID:

  NP_001161962

• Overview:

  Purified recombinant protein of Mouse multiple endocrine neoplasia 1 (Men1), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/17283

• Uniprot URL:

  https://www.uniprot.org/uniprot/O88559

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001168490

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001161962