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Pan3 (BC082547) Mouse Recombinant Protein

CAT: 0882-PM45688M5Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PM45688M5Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Regulatory subunit of the poly (A) -nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly (A) tails of RNA and the activity is stimulated by poly (A) -binding protein (PABP) . PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse PAN3 polyA specific ribonuclease subunit homolog (S, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
2700050F09Rik; A430027N15Rik; AU014670
Gene ID
72587
UniProt
Q640Q5
Accession Number mRNA
BC082547
Chromosomal Location
5 G3
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
62.8 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Pan3
Species
Mouse
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/72587
Uniprot URL
https://www.uniprot.org/uniprot/Q640Q5
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC082547

UniProtKB · Q640Q5

PAN2-PAN3 deadenylation complex subunit Pan3

PAN3_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q640Q5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Pan3
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
—
Secondary accessions
H3BKF3, Q3U5F2, Q8CE75, Q9CZM6
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMetal-bindingNucleotide-bindingZinc

Domain

Coiled coilZinc-finger

Cellular component

CytoplasmNucleus

Biological process

mRNA processing

PTM

Phosphoprotein

Technical term

Reference proteome

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