Hook3 (NM_207659) Mouse Recombinant Protein

• Background:

  Component of the FTS/Hook/FHIP complex (FHF complex) . The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) . May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex (By similarity) . Serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (PubMed:12950921) . Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  5830454D03Rik; AI317159; E330005F07Rik

• Gene ID:

  320191

• UniProt:

  Q8BUK6

• Accession Number mRNA:

  NM_207659

• Chromosomal Location:

  8 A2

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  83.5 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Hook3

• Species:

  Mouse

• Protein ID:

  NP_997542

• Overview:

  Purified recombinant protein of Mouse hook microtubule tethering protein 3 (Hook3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/320191

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8BUK6

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_207659

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_997542