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Cul2 (BC026779) Mouse Recombinant Protein

CAT: 0882-PM45129M5Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PM45129M5Size:20 µg
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Background
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity) . May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity) . The functional specificity of the ECS complex depends on the substrate recognition component. ECS (VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) (By similarity) .[UniProtKB/Swiss-Prot Function]
Overview
Purified recombinant protein of Mouse cullin 2 (cDNA clone MGC:25783 IMAGE:4018298), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
1300003D18Rik; 4932411N15Rik; AI327301; mKIAA4106
Gene ID
71745
UniProt
Q9D4H8
Accession Number mRNA
BC026779
Chromosomal Location
18 A1
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
86.9 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Cul2
Species
Mouse
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/71745
Uniprot URL
https://www.uniprot.org/uniprot/Q9D4H8
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC026779

UniProtKB · Q9D4H8

Cullin-2

CUL2_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q9D4H8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Cul2
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
CUL-2
EC number
—
Processing
—
Secondary accessions
Q3TUR8
Protein keywords

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Cellular component

Nucleus

Technical term

Reference proteome

Biological process

Ubl conjugation pathway

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