Hdac7 (NM_019572) Mouse Recombinant Protein

• Background:

  Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Positively regulates the transcriptional repressor activity of FOXP3 (By similarity) . Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (By similarity) . In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  5830434K02Rik; HD7; HD7a; Hdac7a; mFLJ00062

• Gene ID:

  56233

• UniProt:

  Q8C2B3

• Accession Number mRNA:

  NM_019572

• Chromosomal Location:

  15 F1

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  101.7 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Hdac7

• Species:

  Mouse

• Protein ID:

  NP_062518

• Overview:

  Purified recombinant protein of Mouse histone deacetylase 7 (Hdac7), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/56233

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8C2B3

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_019572

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_062518