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Timeless (BC058641) Mouse Recombinant Protein

CAT: 0882-PM44786M5Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0882-PM44786M5Size:20 µg
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Background
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Overview
Purified recombinant protein of Mouse timeless homolog (Drosophila) (cDNA clone MGC:73470 IMAGE:6837105), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug
Synonyms
Tim, Debt69
Gene ID
21853
UniProt
Q9R1X4
Accession Number mRNA
BC058641
Chromosomal Location
10 76.49 cM
Expression System
HEK293T
Tag
C-MYC/DDK
Concentration
>50 ug/mL as determined by microplate BCA method
Purity
> 80% as determined by SDS-PAGE and Coomassie blue staining
Form
Liquid
Buffer
25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Weight
122 kDa
Storage Conditions
Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.
Symbol
Timeless
Species
Mouse
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/21853
Uniprot URL
https://www.uniprot.org/uniprot/Q9R1X4
Accession Number mRNA URL
https://www.ncbi.nlm.nih.gov/nuccore/BC058641

UniProtKB · Q9R1X4

Protein timeless homolog

TIM_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q9R1X4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Timeless
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
mTim
EC number
—
Processing
—
Secondary accessions
Q63ZX9, Q6P204, Q6PDL4, Q7TPV8, Q8R0Q2, Q9R268, Q9Z0E7
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

Biological rhythmsCell cycleCell divisionDNA damageDNA repairMitosisTranscriptionTranscription regulation

Cellular component

ChromosomeNucleus

Molecular function

Developmental protein

PTM

Phosphoprotein

Technical term

Reference proteome