Eif2ak3 (NM_010121) Mouse Recombinant Protein

• Background:

  The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in a similar gene in human are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015]

• Synonyms:

  PE; Pek; Perk

• Gene ID:

  13666

• UniProt:

  E9QQ30, Q7TQC8

• Accession Number mRNA:

  NM_010121

• Chromosomal Location:

  6 C1

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  125.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Eif2ak3

• Species:

  Mouse

• Protein ID:

  NP_034251

• Overview:

  Purified recombinant protein of Mouse eukaryotic translation initiation factor 2 alpha kinase 3 (Eif2ak3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/13666

• Uniprot URL:

  https://www.uniprot.org/uniprot/E9QQ30

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_010121

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_034251