EIF2AK3 Rabbit pAb (APR24293N)

CAT: 0882-APR24293N-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0882-APR24293N-01Size:50 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality EIF2AK3 Rabbit pAb (APR24287N6) .

Synonyms

EIF2AK3; PEK; PERK; WRS

Gene ID

9451

UniProt

Q9NZJ5

Cellular Locus

Endoplasmic reticulum membrane, Single-pass type I membrane protein

Applications

WB (Rattus norvegicus, Homo sapiens, Mus musculus)

Dilution

WB 1:500 - 1:2000 IF 1:50 - 1:200

Form

Liquid

Buffer

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Molecular Weight

Calculated MW: 125kDa Observed MW: 140KDa

Storage Conditions

Store at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Gene ID URL

https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9451

Uniprot URL

https://www.uniprot.org/uniprot/Q9NZJ5

AA Sequence

Email for sequence

UniProtKB · Q9NZJ5

Eukaryotic translation initiation factor 2-alpha kinase 3

E2AK3_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9NZJ5
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: EIF2AK3
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.7.11.1
Processing: Precursor
Secondary accessions: A0AVH1, A0AVH2, B2RCU9, O95846, Q53QY0, Q53SB1

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

ADP-ribosylationGlycoproteinPhosphoprotein

Ligand

ATP-bindingNucleotide-binding

Disease

Diabetes mellitusDisease variant

Cellular component

Endoplasmic reticulumMembrane

Molecular function

KinaseSerine/threonine-protein kinaseTransferaseTyrosine-protein kinase

Domain

SignalTransmembraneTransmembrane helix

Biological process

Stress responseTranslation regulationUnfolded protein response

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