Lrpprc (BC059862) Mouse Recombinant Protein

• Background:

  May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly (A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly (A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters (By similarity) . Binds single-stranded DNA.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  LSFC, GP130, Lrp130

• Gene ID:

  72416

• UniProt:

  Q6PB66

• Accession Number mRNA:

  BC059862

• Chromosomal Location:

  17 E4

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  160.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Lrpprc

• Species:

  Mouse

• Overview:

  Purified recombinant protein of Mouse leucine-rich PPR-motif containing (cDNA clone MGC:69719 IMAGE:6417407), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/72416

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q6PB66

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/BC059862