Ptprs (BC052462) Mouse Recombinant Protein

• Background:

  Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans (PubMed:19833921, PubMed:21454754, PubMed:22406547) . Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth (PubMed:21454754) . Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection (PubMed:15797710, PubMed:19833921, PubMed:19780196, PubMed:21454754, PubMed:22519304, PubMed:22406547) . Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2 (PubMed:21454754) . Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb (PubMed:10080191) . Functions as tyrosine phosphatase (PubMed:7529177) . Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity) . Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (PubMed:15797710) . Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  PTP-NU3, PTPsigma

• Gene ID:

  19280

• UniProt:

  B0V2N1

• Accession Number mRNA:

  BC052462

• Chromosomal Location:

  17 29.32 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  204.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Ptprs

• Species:

  Mouse

• Overview:

  Purified recombinant protein of Mouse protein tyrosine phosphatase, receptor type, S (cDNA clone MGC:63375 IMAGE:6834684), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/19280

• Uniprot URL:

  https://www.uniprot.org/uniprot/B0V2N1

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/BC052462