Prx (BC068135) Mouse Recombinant Protein

Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells (PubMed:11430802, PubMed:21745462, PubMed:22764250) . Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli (PubMed:10839370) . Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions (PubMed:15356632) . Required for normal remyelination after nerve injury (PubMed:10839370) . Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses; shorter internodes cause slower transmission of nerve impulses (PubMed:15356632, PubMed:23022068) . Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane; the Schwann cell cytoplasm is restricted to regions between these appositions (PubMed:15356632, PubMed:23022068) . Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves (PubMed:23022068, PubMed:22764250) . Recruits DRP2 to the Schwann cell plasma membrane (PubMed:11430802, PubMed:23022068, PubMed:22764250) . Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology (PubMed:21745462) .[UniProtKB/Swiss-Prot Function]

Purified recombinant protein of Mouse periaxin (cDNA clone MGC:92965 IMAGE:30354483), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

L-Periaxin

19153

O55103

BC068135

7 15.91 cM

HEK293T

C-MYC/DDK

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

147.5 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

Prx

Mouse

https://www.ncbi.nlm.nih.gov/gene/19153

https://www.uniprot.org/uniprot/O55103