Bcl2 (NM_009741) Mouse Recombinant Protein

• Background:

  This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and autophagy. Abnormal expression and chromosomal translocations of this gene are associated with cancer progression in numerous tissues. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

• Synonyms:

  AW986256; Bcl-; Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik

• Gene ID:

  12043

• UniProt:

  P10417

• Accession Number mRNA:

  NM_009741

• Chromosomal Location:

  1 49.76 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  26.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Bcl2

• Species:

  Mouse

• Protein ID:

  NP_033871

• Overview:

  Purified recombinant protein of Mouse B cell leukemia/lymphoma 2 (Bcl2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/12043

• Uniprot URL:

  https://www.uniprot.org/uniprot/P10417

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_009741

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_033871