Sema4a (NM_001163491) Mouse Recombinant Protein

• Background:

  Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (PubMed:20043131, PubMed:17318185) . Regulates glutamatergic and GABAergic synapse development (PubMed:29981480) . Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (PubMed:29981480) . Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (PubMed:15780988) . Promotes phosphorylation of TIMD2 (PubMed:12374982) . Inhibits angiogenesis (PubMed:17318185) . Promotes axon growth cone collapse (PubMed:20043131) . Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (PubMed:20043131) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AI132332; Semab; SemB

• Gene ID:

  20351

• UniProt:

  Q62178

• Accession Number mRNA:

  NM_001163491

• Chromosomal Location:

  3 F1

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  83.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Sema4a

• Species:

  Mouse

• Protein ID:

  NP_001156963

• Overview:

  Purified recombinant protein of Mouse sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/20351

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q62178

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001163491

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001156963