Grb14 (NM_016719) Mouse Recombinant Protein

• Background:

  Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR) . Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AI505286

• Gene ID:

  50915

• UniProt:

  Q9JLM9, A2ASX2

• Accession Number mRNA:

  NM_016719

• Chromosomal Location:

  2 C1.3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  60.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Grb14

• Species:

  Mouse

• Protein ID:

  NP_057928

• Overview:

  Purified recombinant protein of Mouse growth factor receptor bound protein 14 (Grb14), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/50915

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9JLM9

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_016719

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_057928