Foxl2 (NM_012020) Mouse Recombinant Protein

• Background:

  Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Is a regulator of CYP19 expression. Is a transcriptional repressor of STAR. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AU045128; BPES; Pfrk; PINTO

• Gene ID:

  26927

• UniProt:

  O88470, Q2TVT7

• Accession Number mRNA:

  NM_012020

• Chromosomal Location:

  9 E3.3

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  39.3 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Foxl2

• Species:

  Mouse

• Protein ID:

  NP_036150

• Overview:

  Purified recombinant protein of Mouse forkhead box L2 (Foxl2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/26927

• Uniprot URL:

  https://www.uniprot.org/uniprot/O88470

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_012020

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_036150