S100a4 (NM_011311) Mouse Recombinant Protein

• Background:

  Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:20519440) . Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:8051043) . Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (PubMed:8051043) . Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity) . Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (PubMed:20103644) . In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  18A2; 42a; Capl; FSp1; metastasin; Mts1; PeL98; pk9a

• Gene ID:

  20198

• UniProt:

  P07091, Q545V2

• Accession Number mRNA:

  NM_011311

• Chromosomal Location:

  3 39.27 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  12.2 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  S100a4

• Species:

  Mouse

• Protein ID:

  NP_035441

• Overview:

  Purified recombinant protein of Mouse S100 calcium binding protein A4 (S100a4), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/20198

• Uniprot URL:

  https://www.uniprot.org/uniprot/P07091

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_011311

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_035441