Ticam2 (NM_173394) Mouse Recombinant Protein

• Background:

  Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response. Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  B430113A10; TICAM-2; Tirp; TRAM; Trif

• Gene ID:

  225471

• UniProt:

  Q8BJQ4

• Accession Number mRNA:

  NM_173394

• Chromosomal Location:

  18 C

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  26.8 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Ticam2

• Species:

  Mouse

• Protein ID:

  NP_775570

• Overview:

  Purified recombinant protein of Mouse toll-like receptor adaptor molecule 2 (Ticam2), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/225471

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q8BJQ4

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_173394

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_775570