Nr1h3 (NM_013839) Mouse Recombinant Protein

• Background:

  Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281) . Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism.[UniProtKB/Swiss-Prot Function]

• Synonyms:

  AU018371; LXR; RLD1; Unr1

• Gene ID:

  22259

• UniProt:

  Q9Z0Y9, Q91X41

• Accession Number mRNA:

  NM_013839

• Chromosomal Location:

  2 50.52 cM

• Expression System:

  HEK293T

• Tag:

  C-MYC/DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

• Molecular Weight:

  50.9 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  Nr1h3

• Species:

  Mouse

• Protein ID:

  NP_038867

• Overview:

  Purified recombinant protein of Mouse nuclear receptor subfamily 1, group H, member 3 (Nr1h3), with C-terminal MYC/DDK tag, expressed in HEK293T cells, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/22259

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9Z0Y9

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_013839

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_038867