LXR alpha (NR1H3) Mouse Monoclonal Antibody [Clone ID: LBI1F5]

• Background:

  The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

• Synonyms:

  LXR-a; LXRA; RLD-1

• Gene Name:

  Nuclear receptor subfamily 1 group H member 3

• Gene ID:

  10062

• UniProt:

  Q13133

• Conjugation:

  Unconjugated

• Related Pathways:

  PPAR signaling pathway

• Field of Research:

  PPAR signaling pathway

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:2000

• Form:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Buffer:

  PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

• Function:

  Druggable Genome, Nuclear Hormone Receptor, Transcription Factors

• Storage Conditions:

  Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

• Symbol:

  NR1H3

• Overview:

  NR1H3 mouse monoclonal antibody, clone LBI1F5

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=10062

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13133