PLA2G2F (NM_022819) Human Recombinant Protein

• Background:

  May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity) . Phospholipase A2, which catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:11112443) . Hydrolyzes phosphatidylethanolamine more efficiently than phosphatidylcholine, with only a modest preference for arachidonic acid versus linoelic acid at the sn-2 position. Comparable activity toward 1-palmitoyl-2-oleoyl-phosphatidylserine vesicles to that toward 1-palmitoyl-2-oleoyl-phosphatidylglycerol (By similarity) . Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference (PubMed:11112443) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  FLJ25429; FLJ36326

• Gene ID:

  64600

• UniProt:

  Q9BZM2

• Accession Number mRNA:

  NM_022819

• Chromosomal Location:

  1p36.12

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Alpha-Linolenic acid metabolism, Arachidonic acid metabolism, Ether lipid metabolism, Fc epsilon RI signaling pathway, Glycerophospholipid metabolism, GnRH signaling pathway, Linoleic acid metabolism, Long-term depression, MAPK signaling pathway, Metabolic pathways, Vascular smooth muscle contraction, VEGF signaling pathway

• Field of Research:

  Alpha-Linolenic acid metabolism, Arachidonic acid metabolism, Ether lipid metabolism, Fc epsilon RI signaling pathway, Glycerophospholipid metabolism, GnRH signaling pathway, Linoleic acid metabolism, Long-term depression, MAPK signaling pathway, Metabolic pathways, Vascular smooth muscle contraction, VEGF signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Function:

  Druggable Genome, Secreted Protein

• Molecular Weight:

  23.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  PLA2G2F

• Species:

  Human

• Protein ID:

  NP_073730

• Overview:

  Recombinant protein of human phospholipase A2, group IIF (PLA2G2F)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/64600

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q9BZM2

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_022819

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_073730