ICOS Ligand (ICOSLG) (NM_015259) Human Recombinant Protein

• Background:

  Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity) .[UniProtKB/Swiss-Prot Function]

• Synonyms:

  B7-H2; B7h; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; LICOS

• Gene ID:

  23308

• UniProt:

  O75144, A0N0L8

• Accession Number mRNA:

  NM_015259

• Chromosomal Location:

  21q22.3

• Expression System:

  HEK293

• Tag:

  C-DDK/His

• Related Pathways:

  Cell adhesion molecules (CAMs)

• Field of Research:

  Cell adhesion molecules (CAMs)

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  PBS, pH7.4, 10% glycerol

• Function:

  Transmembrane

• Molecular Weight:

  29 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  ICOSLG

• Species:

  Human

• Protein ID:

  NP_056074

• Overview:

  Purified recombinant protein of human inducible T-cell co-stimulator ligand (ICOSLG), with C-terminal DDK/His tag, expressed in human cells, 20 µg

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/23308

• Uniprot URL:

  https://www.uniprot.org/uniprot/O75144

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_015259

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_056074