DYRK1A (NM_001396) Human Recombinant Protein

• Background:

  This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]

• Synonyms:

  DYRK; DYRK1; HP86; MNB; MNBH; MRD7

• Gene ID:

  1859

• UniProt:

  Q13627

• Accession Number mRNA:

  NM_001396

• Chromosomal Location:

  21q22.13

• Expression System:

  Sf9

• Tag:

  C-DDK

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase

• Molecular Weight:

  85.6 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  DYRK1A

• Species:

  Human

• Protein ID:

  NP_001387

• Overview:

  Recombinant protein of human dual-specificity tyrosine- (Y) -phosphorylation regulated kinase 1A (DYRK1A), transcript variant 1, full length, with C-terminal DDK tag, expressed in sf9 cells

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1859

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13627

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_001396

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_001387