DYRK1A Antibody (N-term) [APR11812G]

• Background:

  Tissue Location: Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.

• Synonyms:

  Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB, DYRK1A, DYRK, MNB, MNBH

• Gene Name:

  DYRK1A

• Gene ID:

  1859

• UniProt:

  Q13627

• Chromosomal Location:

  Nucleus. Nucleus speckle {ECO:0000250|UniProtKB:Q61214}

• Applications:

  IHC-P, WB

• Dilution:

  WB--1:500-1:2000 IHC-P--1:100~500

• Form:

  Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

• Function:

  Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity) . Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in turn inhibits TP53 activity and apoptosis (By similarity) .

• Molecular Weight:

  85584

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Overview:

  We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality DYRK1A Antibody (N-term) [APR11812G].

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/?term=1859

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q13627