MCSF Receptor (CSF1R) (NM_005211) Human Recombinant Protein

• Background:

  The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. [provided by RefSeq, Mar 2017]

• Synonyms:

  BANDDOS; C-FMS; CD115; CSF-1R; CSFR; FIM2; FMS; HDLS; M-CSF-R

• Gene ID:

  1436

• UniProt:

  P07333

• Accession Number mRNA:

  NM_005211

• Chromosomal Location:

  5q32

• Expression System:

  Sf9

• Tag:

  C-DDK

• Related Pathways:

  Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Pathways in cancer

• Field of Research:

  Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Pathways in cancer

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol

• Function:

  Druggable Genome, Protein Kinase, Transmembrane

• Molecular Weight:

  55.1 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  CSF1R

• Species:

  Human

• Protein ID:

  NP_005202

• Overview:

  Recombinant protein of human colony stimulating factor 1 receptor (CSF1R), residues 20-517aa, with C-terminal DDK tag, expressed in sf9, 20ug

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/1436

• Uniprot URL:

  https://www.uniprot.org/uniprot/P07333

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_005211

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_005202